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\title{PLOS Science Wednesday: Hi Reddit, I'm Zhengquan Yu, here to talk about
my recent PLOS Genetics paper that has identified the key role of a
microRNA in hair loss. I'm joined by Maksim Plikus, who studi}



\author[1]{PLOSScienceWednesday }%
\author[1]{r/Science AMAs}%
\affil[1]{Affiliation not available}%


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  \date{April 23, 2026}


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\begin{abstract}
Hi Reddit, My name is Zhengquan Yu and I am an associate professor at
the China Agricultural University. Joining me in this AMA is my
colleague, Maksim Plikus from the University of California, Irvine, who
studies the principles and mechanisms of adult stem cell regulation
using hair follicle as the primary model system. My research focuses on
regulatory network of somatic stem cells in hair follicle and mammary
gland. We recently published a research article titled
Post-transcriptional Regulation of Keratinocyte Progenitor Cell
Expansion, Differentiation and Hair Follicle Regression by miR-22 in
PLOS Genetics. We describe an essential role for a highly conserved
microRNA, miR-22, in regulating the regression of mouse hair follicles.
We found that increasing miR-22 results in hair loss in mice due to the
premature regression of follicles, and that silencing of
keratin-mediated hair shaft assembly by miR-22 is a prerequisite for
follicle regression. There are hundreds of microRNAs expressed in hair
follicles, but most of them are not well studied. This paper highlights
the importance of determining the combinatorial effects of the microRNA
regulatory network in hair cycling and provides new insights into the
mechanism of premature hair follicle regression in understanding the
pathology of hair loss. We will be answering your questions at 1pm ET
(10 am PT, 5 pm UTC), Ask Us Anything!%
\end{abstract}%



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