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A systematic review on experimental studies about patient adherence to treatment
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  • Frans Folkvord,
  • Ana Roca-Umbert,
  • Karlijn van Houten,
  • Aad Liefveld,
  • Jim Carlson,
  • Nadine Bol,
  • Emiel Krahmer,
  • Gwenn Beets,
  • Rachel Drbohlav Ollerton,
  • Eva Turk,
  • Harald Hrubos-Strom,
  • Hamza Nahoui,
  • Gunnar Einvik,
  • Henrik Schirmer,
  • Anne Moen,
  • Jaime Barrio Cortes,
  • Beatriz Merino,
  • Pena Arroyo,
  • Giuseppe Fico,
  • Luis Midao,
  • Rute Sampaio,
  • Joa Filipe Raposo,
  • Katja Geipel,
  • Kathrin Scheckenbach,
  • Laura de Ruiter,
  • Francisco Lupianez-Villanueva
Frans Folkvord

Corresponding Author:fransfolkvord@gmail.com

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Ana Roca-Umbert
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Karlijn van Houten
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Aad Liefveld
Link2Trials
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Jim Carlson
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Nadine Bol
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Emiel Krahmer
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Gwenn Beets
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Rachel Drbohlav Ollerton
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Harald Hrubos-Strom
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Hamza Nahoui
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Gunnar Einvik
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Henrik Schirmer
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Jaime Barrio Cortes
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Beatriz Merino
Universidad Politécnica de Madrid
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Pena Arroyo
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Giuseppe Fico
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Luis Midao
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Rute Sampaio
University of Porto Faculty of Medicine
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Joa Filipe Raposo
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Katja Geipel
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Kathrin Scheckenbach
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Laura de Ruiter
Astellas Pharma US Inc
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Francisco Lupianez-Villanueva
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Abstract

Better understanding patients’ adherence to treatment is a prerequisite to maximize the benefit of healthcare care provision for patients, reduce treatment costs, and is a key factor in a variety of subsequent health outcomes. We aim to understand the state of the art of scientific evidence about which factors influence patients’ adherence to treatment. A systematic literature review was conducted using PRISMA guidelines in five separate electronic databases of scientific publications: PubMed, PsycINFO (ProQuest), Cochrane library (Ovid), Google Scholar, and Web of Science. The search focused on literature reporting the significance of factors in adherence to treatment between 2011-2021, including only experimental studies (e.g., randomized controlled trials [RCT], clinical trials, etc.). We included 47 experimental studies. The results of the systematic review (SR) are grouped according to predetermined categories of the World Health Organization (WHO): Socioeconomic, Treatment, Condition, Personal, and Healthcare-related factors. This review gives an actual overview of evidence-based studies on adherence and analysed the significance of factors defined by the WHO classification. By showing the strength of certain factors in several independent studies and concomitantly uncovering gaps in research, these insights could serve as a basis for the design of future adherence studies and models.