Well known adverse effects of cryoablation are phrenic nerve and esophageal injury. (1, 2) However, there is very little literature about coronary artery spasm (CAS), a life-threatening complication of cryoablation. We report a case of a 68-year-old Caucasian female, who developed left main coronary spasm (CAS) with significant hemodynamic compromise during cryoablation. Although rare, this complication can be life threatening. Prompt recognition and appropriate intervention is critical for good patient outcome.