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Fatal outcome of Severe Fever With Thrombocytopaenia Syndrome (SFTS) and Severe and Critical COVID-19 is associated with the hyperproduction of IL-10 and IL-6 and the low production of TGF-β
  • +11
  • Keun Hwa Lee,
  • Su Yeon Kang,
  • Jeong Rae Yoo,
  • Yejin Park,
  • So-Hee Kim,
  • Sang Taek Heo,
  • Seong Hyeon Park,
  • Misun Kim,
  • Tae-Jin Kim,
  • Songhyeok Oh,
  • Moo-Seung Lee,
  • Jung Mogg Kim,
  • Nam-Hyuk Cho,
  • Kyung-Mi Lee
Keun Hwa Lee
Hanyang University College of Medicine

Corresponding Author:yomust7@gmail.com

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Su Yeon Kang
Hanyang University College of Medicine
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Jeong Rae Yoo
Jeju National University College of Medicine and Graduate School of Medicine
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Yejin Park
Korea University College of Medicine
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So-Hee Kim
Seoul National University College of Medicine
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Sang Taek Heo
Jeju National University College of Medicine and Graduate School of Medicine
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Seong Hyeon Park
Hanyang University College of Medicine
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Misun Kim
Jeju National University College of Medicine and Graduate School of Medicine
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Tae-Jin Kim
Korea Institute of Radiological and Medical Sciences Library
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Songhyeok Oh
Seoul National University College of Medicine
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Moo-Seung Lee
Korea Research Institute of Bioscience and Biotechnology
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Jung Mogg Kim
Hanyang University College of Medicine
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Nam-Hyuk Cho
Seoul National University College of Medicine
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Kyung-Mi Lee
Korea University College of Medicine
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Abstract

Severe fever with thrombocytopaenia syndrome virus (SFTSV) and Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause the hyperproduction of inflammatory cytokines, which have pathological effects in patient including severe or fatal cytokine storms. To characterize the effect of SFTSV and SARS-CoV-2 infection on the production of cytokines in SFTS and COVID-19 patients, we performed an analysis of cytokines in SFTS and COVID-19 patients and also investigated the role of IL-10 in vitro studies: LPS-induced THP-1-derived macrophages, SFTSV infection of THP-1 cells, and SARS-CoV-2 infection of THP-1 cells. In this study, we found that levels of both IL-10 and IL-6 were significantly elevated, the level of TGF-β was significantly decreased and IL-10 was elevated earlier than IL-6 in severe and critical COVID-19 and fatal SFTS patients, and inhibition of IL-10 signalling decreased the production of IL-6 and elevated that of TGF-β. Therefore, the hyperproduction of IL-10 and IL-6 and the low production of TGF-β have been linked to cytokine storm-induced mortality in fatal SFTS and severe and critically ill COVID-19 patients and that IL-10 can play an important role in the host immune response to severe and critical SARS-CoV-2 and fatal SFTSV infection.
10 Apr 2023Submitted to Journal of Medical Virology
10 Apr 2023Submission Checks Completed
10 Apr 2023Assigned to Editor
10 Apr 2023Review(s) Completed, Editorial Evaluation Pending
13 Apr 2023Reviewer(s) Assigned
11 May 2023Editorial Decision: Revise Major
16 May 20231st Revision Received
16 May 2023Submission Checks Completed
16 May 2023Assigned to Editor
16 May 2023Review(s) Completed, Editorial Evaluation Pending
16 May 2023Reviewer(s) Assigned
12 Jun 2023Editorial Decision: Accept