Abstract
Aims: To explore the impact of a teaching resource on student’s
understanding of variation in drug disposition between ethnic groups.
Methods: A questionnaire was administered to students from medical and
medical sciences undergraduate courses immediately before and after a
teaching session on inter-individual variation in pharmacokinetics.
Responses were analysed using a Wilcoxon signed rank test. Results:
Students were most likely to define ethnicity in relation to culture,
traditions, and place in contrast to use of the term in the
pharmacokinetics literature where it refers to large-scale continental
racial groups, e.g., Black, white, Asian. There was a tendency for
students to assume a genetic mechanism for ethnic differences and there
was a change in this assumption after they participated in the teaching
session. Conclusions: Confusion around the use of the term ethnicity may
contribute towards lack of clarity in teaching and in student
understanding. Teaching about a range of mechanisms that can underly
inter-individual variation in pharmacokinetic processes reduces the
tendency of students to ascribe genetic mechanisms to differences in
drug metabolism, clarifies some of the ways in which individuals can
vary.