Quality assessment
A quality assessment of the studies was performed by two independent reviewers (E.B and T.P) using the Cochrane Collaboration risk of bias tool7. Any disagreement was resolved by discussion or by consulting a third investigator (J.S and /or C.D). We recorded the methods used to generate the randomisation schedule and conceal treatment allocation as well as find out whether blinding was implemented for participants, personnel and outcomes assessment and if there was evidence of incomplete outcomes data and selective reporting of outcomes.