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Endobronchial mucosal nodules and actinomycosis in a child with activated phosphatidylinositol 3-kinase delta syndrome (APDS)
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  • Kwan Fung LAM,
  • Shun CHAN,
  • Lok Sang KAM,
  • Pamela Pui-Wah LEE,
  • Janette Kwok,
  • David Shu-yan Lam
Kwan Fung LAM
Caritas Medical Centre

Corresponding Author:lkf166@ha.org.hk

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Shun CHAN
Tuen Mun Hospital
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Lok Sang KAM
Tuen Mun Hospital
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Pamela Pui-Wah LEE
The University of Hong Kong Department of Paediatrics and Adolescent Medicine
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Janette Kwok
Queen Mary Hospital, Hong Kong
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David Shu-yan Lam
Tuen Mun Hospital
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Abstract

A 5-year-old girl had poor growth and unresolving pneumonia. There was persistent collapse-consolidation of the right middle lobe. CT thorax revealed bilateral bronchial wall thickening and dilatation. Bronchoscopy showed numerous endobronchial mucosal nodules, consisting of dense lymphoid infiltrates. Bacterial culture of the nodule biopsy suggested endobronchial actinomycosis. She had T-cell lymphopenia. Genetic test confirmed the diagnosis of activated phosphatidylinositol 3-kinase delta syndrome (APDS), an immunodeficiency condition.
Aug 2023Published in Respiratory Medicine Case Reports on pages 101909. https://doi.org/10.1016/j.rmcr.2023.101909