loading page

Recent progress on metal-based nanomaterials for cancer radiosensitization
  • +3
  • Xiu Zhao,
  • Jun Li,
  • Qiongwei Wang,
  • Zhenzhong Zhang,
  • Junjie Liu,
  • Jinjin Shi
Xiu Zhao
Zhengzhou University
Author Profile
Jun Li
Zhengzhou University
Author Profile
Qiongwei Wang
Zhengzhou University
Author Profile
Zhenzhong Zhang
Zhengzhou University
Author Profile
Junjie Liu
Zhengzhou University
Author Profile
Jinjin Shi
Zhengzhou University

Corresponding Author:shijinyxy@zzu.edu.cn

Author Profile

Abstract

Radiotherapy is a mainstay treatment for malignant tumors in clinical. However, enhancing radiation damage to tumor cells meanwhile sparing normal tissues is still a great challenge in radiotherapy. Nanomaterials with high atomic number (Z) values are promising radiosensitizers by promoting the radiation energy deposition in irradiated tumor cells, thus enhancing the therapeutic ratio of radiotherapy. In this review, we described the mechanisms of high-Z element radiosensitizers and systematically summarized the recent progress on metal-based nanomaterials, including high-Z metal nanoparticles, metal-organic frameworks (MOFs) and other high-Z-containing nanomaterials. Finally, further potential and challenges in this field were discussed.
16 Mar 2023Reviewer(s) Assigned
26 Apr 2023Review(s) Completed, Editorial Evaluation Pending
03 May 2023Editorial Decision: Revise Minor
30 May 20231st Revision Received
31 May 2023Submission Checks Completed
31 May 2023Assigned to Editor
31 May 2023Review(s) Completed, Editorial Evaluation Pending
31 May 2023Reviewer(s) Assigned
12 Jun 2023Editorial Decision: Accept