The safety, pharmacokinetics, and pharmacodynamics of SHR2285, an oral
small molecule factor XIa inhibitor, in healthy volunteers
Abstract
Aim: The objective of this study was to evaluate the safety,
pharmacokinetics, and pharmacodynamics of SHR2285, a novel small
molecule FXIa inhibitor, in Chinese healthy volunteers. Methods: The
study consisted of single ascending doses part (part A: 25 - 600 mg) and
multiple ascending doses part (part B: 100, 200, 300, and 400 mg). In
both parts, subjects were randomized in a 3:1 ratio to receive SHR2285
or placebo. Plasma and urine samples were collected to describe its
pharmacokinetics and pharmacodynamics (PD) profile. Results: SHR2285
were well tolerated. SHR2285 was absorbed rapidly with median Tmax of
1.50 to 3.00 h. The geometric median of t1/2 of SHR2285 varied from
8.74-12.1 h across 25 to 600 mg single dose. Total systemic exposure of
metabolite SHR164471 was approximately 1.77-3.61 fold that of the parent
drug. The plasma concentration of SHR2285 and SHR164471 reached steady
state by the morning of Day 7 with low accumulation ratio (0.956-1.20
and 1.18-1.56 respectively). The increase in PK exposure of SHR2285 and
SHR164471 was less than dose proportional. Food has minimal effect on
the pharmacokinetics of SHR2285 and SHR164471. SHR2285 produced an
exposure dependent prolongation of APTT, and decrease in FXI activity.
The maximum FXI activity inhibition rate (geometric mean) at steady
state was 73.27%, 85.58%, 87.77% and 86.27% for 100 to 400 mg,
respectively. Conclusions: SHR2285 exhibit a predictable PK profile and
exposure related PD profile. These results suggest that SHR2285 is a
promising novel oral FXI inhibitor warranting further evaluation.