Abstract Objective: This study aimed to identify the association between resilience and social participation, to clarify sub-trajectory of social participation of stroke survivors with different levels of resilience, and to describe stroke survivors with different levels of resilience how to re-integrate into society. Background: Stroke can be considered as a catastrophe which severely affects the social participation of the survivors. Resilience, a buffer against stress and adverse event, its protective effect and mechanism on social participation has not been established. Design: A longitudinal study. The study will be conducted in November 2022 and will continue until January 2024. Methods: First-episode stroke survivors will be recruited from three hospitals, when they had stable vital signs and about to discharge. Follow-up assessments will be performed in 1, 3, 6, 9, and 12 months after stroke survivors’ onset. A multilevel model will be used to explore the relationship between resilience and social participation. Growth Mixture Modeling (GMM) will be used to analyze potential heterogenicity trajectory of social participation. Inductive content analysis will be applied to describe how participants with different levels of resilience return to social life. Conclusions: Our study seeks to examine the association between resilience and social participation and provide a potential perspective of hierarchical intervention programme in enhancing social participation in stroke survivors.