Data Synthesis and Analysis
The synthesis of results was performed using the Guidance on the Conduct of Narrative Synthesis in Systematic Reviews (Popay et al., 2006). The outcomes regarding platinum ototoxicity symptom ease were reported using means (or difference in means) ± standard deviations or means with confidence intervals (CIs) and p values. Epidemiological statistics were reported according to the original articles. The data is presented regarding the efficacy and safety of each intervention. Furthermore, to improve intervention comparisons, the summary information underlines the intention of the intervention (prevention/treatment), the type of assessed ototoxicity (hearing loss, tinnitus, and/or vestibular disturbances), and if other ototoxic treatments were associated with the platinum treatment (e.g. radiotherapy with Gray dose). All authors were involved in analyzing and interpreting the results and vouch for their completeness and accuracy.