A 60-year-old male patient presented skin flushing all over the body, who was diagnosed with toxic epidermal necrolysis syndrome (TEN). According to the suggestions of multi-disciplinary team, the patient was discharged healthily with the comprehensive treatments, including fluid infusion, nutritional support, intravenous gamma globulin and strict skin care. And the follow-up was good. This article is going to summarized experience of this case and review related literature to provide reference for future treatment.