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Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes
  • Jehison Herrera-Pulido,
  • Francois-Michel Boisvert,
  • Francois Boudreau
Jehison Herrera-Pulido
Université de Sherbrooke
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Francois-Michel Boisvert
Université de Sherbrooke
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Francois Boudreau
Université de Sherbrooke

Corresponding Author:francois.boudreau@usherbrooke.ca

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Abstract

HNF4α is a master regulator gene belonging to the nuclear receptor superfamily involved in regulating a wide range of critical biological processes in different organs. Structurally, the HNF4A locus is organized with two independent promoters and is subjected to alternative splicing with the production of twelve distinct isoforms. Little is known about the mechanisms each isoform uses to regulate transcription and their biological impact, with some reports addressing these aspects. Proteomic analyses have led to identifying proteins that interact with specific HNF4α isoforms. The identification and validation of these interactions and their role in co-regulating targeted gene expression are essential to understand better the role of this transcription factor in different biological processes and pathologies. This review addresses the historical origin of HNF4α isoforms, some of the main functions of the P1 and P2 isoform subgroups and provide information on the most recent hot topic research on the nature and function of proteins associated with each of the isoforms in some biological contexts.
31 Jan 2023Submitted to PROTEOMICS
01 Feb 2023Submission Checks Completed
01 Feb 2023Assigned to Editor
01 Feb 2023Review(s) Completed, Editorial Evaluation Pending
01 Feb 2023Reviewer(s) Assigned
20 Mar 2023Editorial Decision: Revise Minor
09 May 2023Review(s) Completed, Editorial Evaluation Pending
09 May 20231st Revision Received
10 May 2023Editorial Decision: Accept