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Pyramidal lobe-dominant papillary thyroid carcinoma - a rare entity with important clinical implications.
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  • Henrique Messias,
  • Maria Luisa Sequeira,
  • Ricardo Nogueira,
  • Carlos Zagalo,
  • Mariluz Martins,
  • Pedro Gomes
Henrique Messias
University of Edinburgh Division of Clinical and Surgical Sciences

Corresponding Author:v1hmessi@ed.ac.uk

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Maria Luisa Sequeira
Francisco Gentil Portuguese Institute for Oncology of Lisbon
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Ricardo Nogueira
Instituto Portugues de Oncologia de Lisboa Francisco Gentil EPE
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Carlos Zagalo
Francisco Gentil Portuguese Institute for Oncology of Lisbon
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Mariluz Martins
Francisco Gentil Portuguese Institute for Oncology of Lisbon
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Pedro Gomes
Francisco Gentil Portuguese Institute for Oncology of Lisbon
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Abstract

Background Papillary thyroid carcinoma (PTC) primarily located in the pyramidal lobe of the thyroid gland is extremely rare, so the clinical and pathological features are not well understood. Case The authors describe a case of multifocal PTC with larger pyramidal lobe tumour, in a 77-year-old female patient who underwent en bloc total thyroidectomy with pyramidal lobe, hyoid bone and cervical lymph node excision. Conclusion In line with the present case, current literature reports a greater presence of worse prognostic factors, namely extrathyroidal extension, advanced T stage or presence of cervical lymph node metastasis. Recently, a new classification has been suggested – Upper Neck Papillary Thyroid Cancer (UPTC) – which encompasses these carcinomas, Delphi ganglion metastases and thyroglossal duct cyst carcinomas, with potential clinical and therapeutic implications, particularly the need for orthotopic thyroidectomy. Also, the complete excision of the pyramidal lobe during thyroidectomy may influence the success of radioactive iodine therapy and the patient’s follow-up surveillance.