Statistical Analysis
Data were analyzed using IBM SPSS Statistics 21.0. Categorical variables
were represented as number and percentage, continuous numerical
variables were represented as mean, standard deviation, minimum and
maximum values. Distribution analysis was done by the Shapiro-Wilk
method. Parametric data were compared with Spearman correlation test and
nonparametric data with Wilcoxon test. p < 0.05 was considered
to indicate statistical significance.
Results
The characteristics of the pregnant women are given in Table 1.
Sixty-eight percent of women had comorbidities. The major comorbidity
was gestational diabetes and hypothyroidism (26% and 22% of women,
respectively). Ten percent of women had pregestational hypertension. The
other comorbidities were coronary artery disease and chronic kidney
disease. All of the women were on
antihypertensive medication. Laboratory work-up of the pregnants are
shown in Table 2.
Ultrasound finding of the fetuses and gestationa age are given in Table
3. Mean umbilical artery systolic/diastolic ratio, umbilical artery
pulsatility index and median cerebral artery pulsatility index were 3.1
± 1.05, 1.18 ± 0.16 and 1.32 ± 0.13, respectively.
Eighty-two percent of the women had a Cesarean section. The mean APGAR
scores at one and five minutes were 6.1 and 7.9, respectively.
The magnesium serum levels before and after magnesium sulfate
prophylaxis are shown in Table 4. The increase in magnesium serum levels
after seizure prophylaxis was 2.6 mg/dL and 0.07 in MPI (Figure 1).
There were no correlations between MPI difference and age, BMI, gravida,
parity, abortus, hemoglobin, thrombocyte count, white blood cell count,
liver function tests, creatinine, fibrinogen, INR, gestational week,
biparietal diameter, head circumference, abdominal circumference, femur
length, umbilical artery SD, PI, RI, middle cerebellar artery peak
systolic velocity, APGAR scores, or serum magnesium level difference.