Variable 2-weeks after 1st vaccination 2-weeks after 1st vaccination 2-weeks after 1st vaccination 2-8 weeks after 2nd vaccination 2-8 weeks after 2nd vaccination 2-8 weeks after 2nd vaccination 2-8 weeks after 3rd vaccination 2-8 weeks after 3rd vaccination 2-8 weeks after 3rd vaccination
AIIRD (n=124) Controls (n=80) P value AIIRD (n=124) Controls (n=80) P value AIIRD (n=64) Controls (n=30) P value
Local reactions 88 (71%) 44 (55%) 0.03 89 (72%) 44 (55%) 0.02 25 (39%) 22 (73%) 0.004
Systemic reactions, n (%) Systemic reactions, n (%) Systemic reactions, n (%) Systemic reactions, n (%) Systemic reactions, n (%) Systemic reactions, n (%) Systemic reactions, n (%) Systemic reactions, n (%) Systemic reactions, n (%) Systemic reactions, n (%)
Fever 6 (5%) 2 (2%) 0.64 18 (15%) 8 (10%) 0.47 7 (11%) 1 (3%) 0.40
Chills 5 (4%) 2 (2%) 0.84 17 (14%) 3 (4%) 0.04 4 (6%) 1 (3%) 0.92
Runny nose 4 (3%) 6 (5%) 1 (1%) 0.32 1 (2%)
Cough 3 (2%) 5 (4%) 1 (1%) 0.46 1 (2%)
Nausea 5 (4%) 2 (2%) 0.84 6 (5%) 2 (2%) 0.63 3 (5%)
Vomiting 1 (1%) 2 (2%) 0.69 3 (2%) 2 (2%) 1 0 (0%)
Fatigue/ weakness 14 (11%) 6 (8%) 0.51 33 (27%) 12 (15%) 0.07 9 (14%) 2 (7%) 0.48
Myalgia 12 (10%) 6 (8%) 0.77 23 (19%) 7 (9%) 0.08 6 (9%) 2 (7%) 0.96
Arthralgia 7 (6%) 1 (1%) 0.22 14 (11%) 2 (2%) 0.04 2 (3%)
Headache 10 (8%) 8 (10%) 0.82 29 (23%) 9 (11%) 0.04 8 (12%) 2 (7%) 0.61
Chest pain 0 (0%) 0 (0%) 3 (2%)
Pericarditis or myocarditis 0 (0%) 0 (0%) 0 (0%)
Herpes zoster 0 (0%) 0 (0%) 0 (0%)
Allergic reaction 0 (0%) 1 (1%) 0.82 0 (0%) 0 (0%)
Exacerbation of rheumatic disease symptoms 5 (4%) 3 (2%) 0 (0%)
Hospitalization within 2 weeks post-vaccine 2 (2%) 0 (0%) 0 (0%)