A five-year-old spayed female Golden Retriever was presented with fever, lethargy, and pollakiuria. Labwork and Imaging inciting a diagnosis of Immune-mediated Hemolytic Anemia, Immune-mediated Thrombocytopenia, and primary Hypothyroidism. but the patient relapsed despite the treatment. A bone marrow cytology/biopsy revealed erythroid predominance and dyserythropoiesis confirming secondary myelodysplastic syndrome.