Author Contributions:
Xipeng wang ,Jun Zhang and Xingchen Zhou had full access to all of the data in the
study and take responsibility for the integrity of the data and accuracy of the data
analysis.
Study concept and design: Xipeng Wang and Jun Zhang.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Xingchen Zhou and Zhenyan Gao.
Critical revision of the manuscript for important intellectual content: Xipeng Wang
and Jun Zhang.
Statistical analysis: Zhenyan Gao
Obtained funding: Xipeng Wang
Administrative, technical, or material support: Huihui Chen; Yizhi Wang and Yujia
Yin
Study supervision: Xipeng Wang
Conflict of interest: The authors report no conflict of interest.
Acknowledgements: The subjects in this trial have not concomitantly been involved
in other randomized trials. Data regarding any of the subjects in the study has not been previously published unless specified. Data will be made available to the editors of the journal for review or query upon request.