loading page

Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are associated with prognosis of patients: a clinical high-grade endometrial carcinoma prognostic model
  • +21
  • zhaoyang zhang,
  • Kun Song,
  • Ran Chu,
  • Jihong Liu,
  • Jieqing Zhang,
  • Hongyan Guo,
  • Min Xia,
  • Penglin Liu,
  • Yue Zhang,
  • Jie Feng,
  • Qiannan Wang,
  • Shu Yao,
  • Shuzhong Yao,
  • Xipeng Wang,
  • Bei Lin,
  • Weidong Zhao,
  • Xiaomao Li,
  • Ping Zhang,
  • Xia Zhao,
  • Jianliu Wang,
  • Ding Ma,
  • Yang Li,
  • Gang Chen,
  • Beihua Kong
zhaoyang zhang
Qilu Hospital of Shandong University
Author Profile
Kun Song
Shandong University Qilu Hospital
Author Profile
Jihong Liu
Sun Yat-sen University Cancer Center
Author Profile
Jieqing Zhang
Author Profile
Hongyan Guo
Author Profile
Penglin Liu
Shandong University Qilu Hospital
Author Profile
Yue Zhang
Qilu Hospital of Shandong University
Author Profile
Jie Feng
Shandong University Qilu Hospital
Author Profile
Qiannan Wang
Shandong University Qilu Hospital
Author Profile
Shu Yao
Shandong University Qilu Hospital
Author Profile
Shuzhong Yao
Author Profile
Xipeng Wang
Author Profile
Weidong Zhao
Author Profile
Xiaomao Li
Author Profile
Ping Zhang
Author Profile
Xia Zhao
Sichuan University West China Second University Hospital Department of Obstetrics and Gynecology
Author Profile
Jianliu Wang
Author Profile
Ding Ma
Huazhong University of Science and Technology Tongji Medical College
Author Profile
Yang Li
Women's Hospital School of Medicine Zhejiang University
Author Profile
Gang Chen
Tongji Hospital of Tongji Medical College of Huazhong University of Science and Technology
Author Profile
Beihua Kong
Shandong University Qilu Hospital

Corresponding Author:kongbeihua@126.com

Author Profile

Abstract

Objectives: To evaluate the predictive significance of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in the prognosis of high-grade endometrial carcinoma and to establish a novel predictive model. Design: A retrospective multicenter study. Setting: Fifteen hospitals of the Chinese Endometrial Carcinoma Consortium. Population: This study included 910 high-grade epithelial endometrial carcinoma patients from the multicenter who underwent initial surgical treatment between January 1, 2005, and December 31, 2019. Methods: Data was retrospectively obtained from the medical records and follow-up information of patients. Cox proportional hazard regression models were developed to predict the risk of recurrence and death at 3, 5, and 10 years, and the models were validated and calibrated. The area under the curve was used to measure the predictive performance of the model. Main outcomes measures: Disease-free survival and overall survival. Result: Platelet-lymphocyte ratio and neutrophil-lymphocyte ratio were risk factors for recurrence, and neutrophil-lymphocyte ratio was a risk factor for death. We established models for predicting death and recurrence. In the validation cohort, the area under receiver operating characteristic curve of disease-free survival model at 3,5 and 10 years was 0.72, 0.77, 0.77, and of overall survival model was 0.72, 0.81, and 0.84. Kaplan–Meier survival analysis showed a significant difference between low-risk and high-risk groups. Conclusions: Neutrophil-lymphocyte ratio and platelet-lymphocyte ratio are risk factors affecting the prognosis of high-grade endometrial carcinoma patients. This novel prediction model for high-grade endometrial carcinoma can provide accurate postoperative risk classification and prognosis prediction for patients. Keywords: Endometrial carcinoma, prognostic model, neutrophil-lymphocyte ratio, platelet-lymphocyte ratio