Curie Scores at Initial Diagnosis
For tandem transplant recipients (n=80), the 3-year EFS and OS from
diagnosis were 65.0±5.4% and 73.5±5.0% respectively. The median Curie
score at diagnosis was 20 (range 1-28) (FIGURE 1A) . The optimal
cut point at diagnosis was a CS=12. Three-year EFS was significantly
higher for patients with a CS≤12 at diagnosis (74.2±7.9%) when compared
to patients with a CS>12 (59.2±7.1%), p=0.002(TABLE 2) (FIGURE 2A) . The 3-year OS was likewise significantly
higher for patients with a CS≤12 vs >12 at diagnosis,
87.1±6.0% vs 64.6±7.0%, p=0.017.
MYCN amplification data were available for 68 of the 80 patients
in the tandem transplant cohort, including 29 patients withMYCN -amplified and 39 patients with MYCN non-amplified
(MYCN- NA) disease (TABLE 3) . At diagnosis, median Curie
scores were higher for patients with MYCN -NA [CS=22 (range
1-26)] vs MYCN -amplified disease [CS=7 (range 1-27)]. A
survival advantage was noted for a small cohort of patients withMYCN -amplified disease who exhibited a CS< 12 at
diagnosis, when compared to those with a CS>12(FIGURE 2B) . No survival advantage by diagnostic CS was noted
for a similar cohort of patients with MYCN -NA disease