3.2 Genetically predicted urinary MMA% and DMA% are associated with chronic pruritus
In the MR analysis, 408,823 participants of the UK Biobank were included (supplementary Table S2). The odds for chronic pruritus was 1.043 (95% CI: 1.003, 1.084;P =0.036) in participants with a PRSMMA% above median versus under median. The odds for chronic pruritus was 0.904 (95% CI: 0.807, 1.011; P =0.078) in participants with a PRSDMA% above versus under median (Figure 2). The results consistently support the causal relationship between genetic susceptibility to arsenic exposure and chronic pruritus.