Declaration of Competing Interest:
The authors declare that they have no known competing financial
interests or personal relationships that could have appeared to
influence the work reported in this paper.
Author contributions: All authors participated in the field
survey and collection of biological samples. X.H., Y.X., and D.J.
performed the dermatological examinations. Senior dermatologists J.S.,
M.C., and X.C. were responsible for quality control for diagnosis. X.H.,
M.H., and Z.H. measured the biological samples. Y.H. performed the
animal experiment. X.H., M.S., and S.Y. analyzed the data and drafted
the manuscript. Z.H., M.H., J.S., M.C., X.C., and M.S. designed the
study, critically reviewed and revised the manuscript. X.C. and M.S.
obtained the funding and contributed the conceptualization of the study.
All authors gave final approval to the version submitted for
publication.