3.2 Genetically predicted urinary MMA% and DMA% are associated
with chronic pruritus
In the MR analysis, 408,823
participants of the UK Biobank were included (supplementary Table S2).
The odds for chronic pruritus was 1.043 (95% CI: 1.003, 1.084;P =0.036) in participants with a PRSMMA% above
median versus under median. The odds for chronic pruritus was 0.904
(95% CI: 0.807, 1.011; P =0.078) in participants with a
PRSDMA% above versus under median (Figure 2).
The results consistently support
the causal relationship between
genetic susceptibility to arsenic exposure and chronic pruritus.