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Bronchopulmonary Dysplasia and Diuretic Use in the Outpatient Setting
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  • Julianne McGlynn,
  • Amanda Martin,
  • Brianna Aoyama C,
  • Nic Bamat,
  • Joseph Collaco,
  • Sharon McGrath-Morrow
Julianne McGlynn
The Children's Hospital of Philadelphia
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Amanda Martin
The Children's Hospital of Philadelphia
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Brianna Aoyama C
The Johns Hopkins University School of Medicine
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Nic Bamat
The Children's Hospital of Philadelphia Division of Neonatology
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Joseph Collaco
The Johns Hopkins University School of Medicine
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Sharon McGrath-Morrow
The Children's Hospital of Philadelphia

Corresponding Author:mcgrathmos@chop.edu

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Abstract

Introduction: During NICU hospitalization, children born preterm with bronchopulmonary dysplasia (BPD) are frequently prescribed diuretics for treatment of respiratory symptoms. However, less is known about diuretic use and weaning in the outpatient setting. This study sought to characterize clinical features associated with outpatient diuretic use, and timing of diuretic weaning in children with BPD. Methods: Data was obtained by chart review from registry 1224 participants born < 32 weeks gestation, discharged between 2008-2023 and recruited from outpatient BPD clinics at Johns Hopkins Children’s Center and the Children’s Hospital of Philadelphia (97.4% diagnosed with BPD). Data was analyzed using Chi-square tests, t-tests, and ANOVA tests. Results: Children with BPD prescribed diuretics as outpatients (n=737), were more likely to have lower birth weights, earlier gestational age, and severe BPD compared to those not on diuretics (n=487). Of those prescribed diuretics, most children were on a thiazide alone (46.4%) or a thiazide and a potassium sparing agent (44.8%) with a minority on loop diuretics alone (3.3%) or loop diuretic combinations (4.7%). Most children weaned off diuretics by two years of age. Public insurance, earlier gestational age, technology dependence and loop diuretics were associated with slower diuretic weaning. Conclusion: Outpatient diuretic use is common in BPD with > 75% of children being weaned by two years of age. No difference was found in weaning of home oxygen between children on one versus no diuretic. Thiazides were most commonly prescribed with slower outpatient diuretic weaning associated with public insurance, technology dependence and loop diuretic use.
02 Jun 2024Submitted to Pediatric Pulmonology
08 Jun 2024Reviewer(s) Assigned
15 Jul 20241st Revision Received
16 Jul 2024Review(s) Completed, Editorial Evaluation Pending
16 Jul 2024Submission Checks Completed
16 Jul 2024Assigned to Editor
16 Jul 2024Reviewer(s) Assigned
12 Aug 2024Editorial Decision: Accept