5. Conclusion
This study comprehensively explores the epidemiological trends and genetic variations of RV infections among hospitalized children on Hainan Island, spanning from before to after the ending of the Dynamic Zero-COVID Policy. It reveals significant insights into the prevalence, diversity, and seasonal fluctuations of RV, as well as the impact of public health policies on these dynamics. Notably, it highlights the changing dominance among RV strains over time and the specific susceptibility patterns seen across different age groups, genders, and conditions like asthma. The study deepens our understanding of RV circulation and diseases, significantly aiding translational research to establish relevant infection models. This essential knowledge facilitates the creation of targeted therapies, particularly aiding those most vulnerable to RV-induced illnesses.