Funding
This work was supported by Key Research and Development Plan of Hainan Province (No. ZDYF2020150, and ZDYF2022SHFZ085), the National Natural Science Foundation of China (Nos. 32060015, 81860367 and 82060378), CAMS Innovation Fund for Medical Sciences (CIFMS)” (grant 2021-I2M-1-037), the Major Science and Technology Program of Hainan Province (No. ZDKJ202003), the Hainan Provincial Natural Science Foundation of China (Nos. 820RC628 and 2019RC218), the Scientific Research Foundation of the Higher Education Institutions of Hainan Province, China (No. Hnky2021-40), the Research Project of the Hainan Academician Innovation Platform (No. YSPTZX202004), the Hainan Talent Development Project (No. SRC200003), Graduate student innovation grant of Hainan Medical University (No. Hys2020-33, and Qhys2021-356).