Our aim is to show the supportive effect of Aronia melanocarpa(A. melanocarpa) extract on the bladder damage caused by cyclophosphamide(CYC) in the delayed period. For this purpose,the extract was evaluated in gas chromatography.Oral gavage(every other day) of A.melanocarpa was started one month after Wistar rats were given 100mg/kg CYC.After oral gavage repeated 15 times,sacrification was performed and the bladder tissue was examined histologically.P38 MAP Kinase,an inflammatory marker,total antioxidant(TAS) and oxidant(TOS) status were evaluated in serums and urines. There was no difference between the groups in terms of P38 MAPK,TAS, and TOS.In histology, while the histological damage continued in the injury group,A.melanocarpa tissue level improved in the treatment group. According to the experimental results,the fact that A.melanocarpa extract improves the histological damage caused by CYC in the delayed period,and the serum and urine findings were the same as the controls,brought up the therapeutic effect of A.melanocarpa in urotoxicity.