Case presentation:
A 34-year-old woman was referred to our clinic complaining from psoriasiform plaques (Figure1,2). The plaques were originated from 12 years ago in the multiple areas of the body and progressed gradually in the extent of skin involvement. No associating signs were reported and no other past medical, pharmacological, or family history were present. Physical examination revealed multiple indurated, well-demarcated erythematous plaques with thick psoriasiform scales all over the chest, abdomen, back, and upper and lower extremities. Her face was nearly spared with normal hair and nails. Neither lymphadenopathy nor other systemic symptoms were found. Except for the cutaneous findings, physical examination revealed normal findings of other organs. The lesions on the affected skin area were biopsied and the pathology report confirmed a diagnosis of MF and the presence of 60% neutrophils, 30% lymphocytes (3% atypical), 8% monocytes, and 1% eosinophils. The patient underwent PUVA therapy and weekly methotrexate injection, and was prescribed with oral prednisolone 2.5 mg daily for the first month followed by 1.25 mg daily during the next months, a topical ointment including 90% ucerin and 10% urea once daily, and a topical ointment of 50% clobetasol and 50% ucerin once every night. After one month of the treatment significant improvement in all the lesions were observed.After one year of the treatment the disease was completely recovered and treatment with PUVA was significantly efficient (Figure3,4).