The Cape Verde archipelago is a group of Ocean Islands in the Central Atlantic that forms two chains of islands trending Northwest and Southwest. Several of the islands are considered to be volcanically active, with frequent eruptions on Fogo. We examine the mineral chemistry and thermobarometry of the southern islands; Santiago, Fogo and Brava together with the Cadamosto Seamount. Our objective is to explore the magmatic storage system and implications for volcanic eruptions and associated hazards at Cape Verde. The volcanic rocks at Cape Verde are alkaline and dominantly mafic, whereas the island of Brava and the Cadamosto Seamount are unusually felsic. Clinopyroxene compositions range from 60 to 90 Mg# at Santiago and Fogo. In contrast, at Brava and the Cadamosto Seamount the clinopyroxene compositions are 5 to 75 Mg#. Mineral chemistry and zonation records fractional crystallization, recharge, aggregation of crystals, magma mixing and variations in thermal conditions of the magma at temperatures from 925 to 1250C. Magma storage depths at Santiago, Fogo, Brava and the Cadamosto Seamount are between 12 and 40 km, forming deep sub-Moho magma storage zones. Transient magma storage in the crust is suggested by fluid inclusion re-equilibration and pre-eruption seismicity. A global compilation of magma storage at Ocean Islands suggests deep magma storage is a common feature and volcanic eruptions are often associated with rapid magma ascent through the crust. Shallow magma storage is more variable and likely reflects local variations in crustal structure, sediment supply and tectonics. Petrological constraints on the magma plumbing system at Cape Verde and elsewhere are vital to integrate with deformation models and seismicity in order to improve understanding and mitigation of the volcanic hazards.