Amanita Phalloides is a poisonous mushroom belonging to Amanitaceae family. It is one of the most dangerous mushrooms known to date and the ingestion of its part leads to death in 70/80% of cases if not treated. Here we presented a case of a patient with amanita intoxication treated with CRRT + CytoSorb before liver transplantation. The therapy seems to be effective in the patient’s haemodynamics stabilization and reducing serum amanitin levels. Unfortunately, the patient died as a result of post-operative complications.