Improved knowledge of the contributing sources of uncertainty in projections of Arctic sea ice over the 21st century is essential for evaluating impacts of a changing Arctic environment. Here, we consider the role of internal variability, model structure and emissions scenario in projections of Arctic sea-ice area (SIA) by using six single model initial-condition large ensembles and a suite of models participating in Phase 5 of the Coupled Model Intercomparison Project. For projections of September Arctic SIA change, internal variability accounts for as much as 40-60% of the total uncertainty in the next decade, while emissions scenario dominates uncertainty toward the end of the century. Model structure accounts for approximately 60-70% of the total uncertainty by mid-century and declines to 30% at the end of the 21st century during the summer months. For projections of wintertime Arctic SIA change, internal variability contributes as much as 50-60% of the total uncertainty in the next decade and impacts total uncertainty at longer lead times when compared to the summertime. Model structure contributes most of the remaining uncertainty with emissions scenario contributing little to the total uncertainty during the winter months. At regional scales, the contribution of internal variability can vary widely and strongly depends on the month and region. For wintertime SIA change in the GIN and Barents Seas, internal variability contributes approximately 60-70% to the total uncertainty over the coming decades and remains important much longer than in other regions. We further find that the relative contribution of internal variability to total uncertainty is state-dependent and increases as sea ice volume declines. These results demonstrate the need to improve the representation of internal variability of Arctic SIA in models, which is a significant source of uncertainty in future projections.