67-year-old presented with subacute left temporal lobe infarction, lumbar spine osteomyelitis, and aortic valve vegetation. Further investigations demonstrated Abiotrophia defectiva bacteremia. He was treated with penicillin and gentamicin, discharged with 4 weeks ceftriaxone. We wish to raise awareness of complications of A. defectiva endocarditis and encourage further research into treatment.

Primary cardiac tumors are extremely rare, and can lead to significant neurologic symptoms if not diagnosed and treated appropriately. Simultaneous myxoma and valvular insufficiency is rare. This is the rare case of a patient with a left atrial myxoma and aortic insufficiency leading to cerebrovascular symptoms.