In order to improve the motion accuracy and stability of six degrees of freedom (6-DOF) motion platform, a control strategy of 6-DOF motion platform based on hybrid heuristic algorithm is proposed in this article. Based on the kinematics and dynamics equations of the 6-DOF motion platform, the PID control system of the 6-DOF motion platform is constructed, the optimization model of the 6-DOF motion platform is established by combining MATLAB/Simulink, and the optimization results are verified. The results show that, compared with the Z-N method PID control strategy, the system step overshoot is 3.80% and the dynamic performance is improved by 75.86% when the hybrid heuristic algorithm is used for PID control, the motion error of each electric cylinder is ±0.1 mm when controlling the 6-DOF motion platform, and the motion accuracy is improved by 67%. The optimized control strategy proposed in this article provides a technical reference for the performance control research of 6-DOF motion platforms and applications in vehicle vibration testing.