RESULTS:
The original search retrieved 689 unique citations, six additional articles were found via references and three via Pubmed alerts, of which 44 were full-text screened. The final search retrieved 8 additional articles which were full-text screened. Overall, 26 studies were included (Fig. 1 and Table 1). Of them, five were randomized, double-blinded, placebo-controlled (RDBPC) studies12-16, one non-randomized, placebo-controlled17, eight prospective cohorts, including two conference abstracts18-25, five observational studies26-30, three retrospective studies31-33, one follow-up study34, and three case reports35-37.
Participants with hazelnut allergy were included in 19 studies, walnut 18, cashew 16, pecan 13, almond 12, and pistachio 8 (Appendix 2).
Efficacy and Safety