RESULTS:
The original search retrieved 689 unique citations, six additional
articles were found via references and three via Pubmed alerts, of which
44 were full-text screened. The final search retrieved 8 additional
articles which were full-text screened. Overall, 26 studies were
included (Fig. 1 and Table 1). Of them, five were randomized,
double-blinded, placebo-controlled (RDBPC)
studies12-16, one non-randomized,
placebo-controlled17, eight prospective cohorts,
including two conference abstracts18-25, five
observational studies26-30, three retrospective
studies31-33, one follow-up study34,
and three case reports35-37.
Participants with hazelnut allergy were included in 19 studies, walnut
18, cashew 16, pecan 13, almond 12, and pistachio 8 (Appendix 2).
Efficacy and Safety