Article type : Original article
Title : Prenatal antibiotic exposure and the risk of atopic
dermatitis in children: a nationwide population-based cohort study.
Running title : Prenatal antibiotics and risk of atopic
dermatitis.
Keywords : Antibiotics, atopic dermatitis, gestational
infection, acetaminophen, microbial dysbiosis
Authors :
Yu-Chuan Chang,1 MD, Meng-Che Wu,2-4MD, PhD, Hsing-Ju Wu5-7, PhD, Pei-Lun Liao,
MS8, James Cheng-Chung Wei3, 9, 10MD, PhD
1Department of Pediatrics, Chang Bing Show Chwan
Memorial Hospital, Changhua;
2Division of Gastroenterology, Children’s Medical
Center, Taichung Veterans General Hospital, Taichung;
3Institute of Medicine, Chung Shan Medical University,
Taichung;
4College of Medicine, National Chung Hsing University,
Taichung;
5Department of Biology, National Changhua University
of Education, Changhua;
6Research Assistant Center, Show Chwan Memorial
Hospital, Changhua;
7Department of Medical Research, Chang Bing Show Chwan
Memorial Hospital, Changhua;
8Department of Medical Research, Chung Shan Medical
University Hospital, Taichung;
9Division of Allergy, Immunology and Rheumatology,
Chung Shan Medical University Hospital, Taichung;
10Graduate Institute of Integrated Medicine, China
Medical University, Taichung
All in Taiwan.
Yu-Chuan Chang and Meng-Che Wu contributed equally.
Corresponding author :
James Cheng-Chung Wei, M.D., Ph.D.,
Department of Allergy, Immunology & Rheumatology, Chung Shan Medical
University Hospital
No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung City 40201,
Taiwan
TEL: +886 4 24739595 #34718, 34308
FAX: +886 4 24734323
Email: jccwei@gmail.com
Manuscript word count : 3165
Abstract word count : 271
References : 33
Figures : 1
Supplementary figures : 1
Tables : 5
Supplementary tables : 1
Funding sources : This study was supported by the DryLab Team of
Chung Shan Medical University, Taichung, 47 Taiwan.
Conflicts of interest : The authors have no conflicts of
interest that are directly relevant to the content of this article.
IRB approval status : Reviewed and approved by the ethical
review board of Chung Shan Medical University Hospital (No. CS1-21022).
Author contributions : Study concept and design: Y-C C, M-C W,
H-J W. Statistical analysis: P-L L. Analysis and interpretation of data:
Y-C C, M-C W. Drafting of the manuscript: Y-C C, M-C W. Critical
revision of the manuscript for important intellectual content: M-C W,
H-J W, J-C W. All authors read and approved the final manuscript.