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A rare and challenging case:Infective endocarditis and pulmonary hypertension in a patient with Alagille Syndrome and bicuspid aortic valve
  • +2
  • Emre Özmen,
  • Gulsum Bingol,
  • Özge Özden Tok,
  • Federico Landra,
  • Matteo Cameli
Emre Özmen
Siirt Training and Research Hospital Cardiology Department

Corresponding Author:dremreozmen@yahoo.com

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Gulsum Bingol
Memorial Bahçelievler Hospital Cardiology Department
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Özge Özden Tok
Memorial Bahçelievler Hospital Cardiology Department
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Federico Landra
Division of Cardiology Department of Medical Biotechnologies University of Siena Siena Italy
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Matteo Cameli
Division of Cardiology Department of Medical Biotechnologies University of Siena Siena Italy
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Abstract

Alagille syndrome is a genetic disease with multi-organ involvement and can cause various congenital cardiac lesions. This syndrome is caused by mutations in the JAG1 and NOTCH gene pathways. As a result of these lesions, pulmonary hypertension can be seen in patients. While pulmonary hypertension is observed especially due to pulmonary valve stenosis; It may be due to various causes such as tetralogy of Fallot. Currently, pulmonary hypertension has not been reported in Alagille patients without cardiac anomaly in the literature.