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Epidemiology of monoclonal gammopathy in Morocco- A hospital-based study Running Head: Monoclonal gammopathy
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  • Zhor Ouzzif,
  • KAMAL DOGHMI,
  • nezha messaoudi,
  • Sanae Bouhsain,
  • SAMIRA EL MACHTANI IDRISSI,
  • Asmâa Biaz,
  • Achraf Rachid,
  • Abdellah Dami,
  • Ahmed BEZZA,
  • AISSAM EL MAATAOUI
Zhor Ouzzif
Hopital Militaire d'Instruction Mohammed V

Corresponding Author:zahra_ouzzif@yahoo.com

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KAMAL DOGHMI
Hopital Militaire d'Instruction Mohammed V
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nezha messaoudi
Hopital Militaire d'Instruction Mohammed V
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Sanae Bouhsain
Hopital Militaire d'Instruction Mohammed V
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SAMIRA EL MACHTANI IDRISSI
Hopital Militaire d'Instruction Mohammed V
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Asmâa Biaz
Hopital Militaire d'Instruction Mohammed V
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Achraf Rachid
Hopital Militaire d'Instruction Mohammed V
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Abdellah Dami
Hopital Militaire d'Instruction Mohammed V
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Ahmed BEZZA
Hopital Militaire d'Instruction Mohammed V
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AISSAM EL MAATAOUI
Universite Ibn Zohr
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Abstract

Introduction: Monoclonal gammopathies are a group of disorders associated with monoclonal proliferation of plasma cells that produces a monoclonal protein. To describe the epidemiological and immunochemical characteristics of monoclonal gammopathies diagnosed during a nineteen-year period in a Moroccan teaching hospital was the main objective of this study. Methods: This study was performed from January 2000 to August 2019. It was a retrospective study that included of 545 Moroccan patients with monoclonal gammopathy. Results: The patients who participated in the study, 374 (68.6%) were male and 171(31.4%) were female, with a mean ±SD age of 62.24±13.14 years. The most frequent reasons for admission were bone pain (41,60%), renal failure (19.08%), alteration of the general condition (12.21%) and anemia (10.69). Plasma cell proliferative disorders in our study were as follow, multiple myeloma (MM) (45.65%), Monoclonal gammopathies of undetermined significance (MGUS) (39.05%), Waldenstrom’s macroglobulinemia(5.58%), Lymphoma (2.27%+1.2%), Chronic Lymphocytic Leukemia (2.48%), Plasma cell leukemia (1.86%), Plasmacytoma (0.62%), POEMS syndrome (0.41%), and Amyloidosis (0.84%). The most frequent isotypes in MM were the IgGκ (62) 36.5%, IgGλ(52)30.6%, IgAκ(27)15.9% and the IgAλ (19)11.2%. It is also worthy of note, that Free light chain MM represents 20% of all cases of MM. Conclusions: This is the largest Moroccan cohort, it included 545 patients. The results of this study point to the need for an early diagnosis of monoclonal gammopathies in the Moroccan population
17 Oct 2022Submitted to Cancer Reports
19 Oct 2022Submission Checks Completed
19 Oct 2022Assigned to Editor
02 Nov 2022Review(s) Completed, Editorial Evaluation Pending
03 Nov 2022Reviewer(s) Assigned
07 Dec 2022Editorial Decision: Revise Major
15 Dec 20221st Revision Received
20 Dec 2022Review(s) Completed, Editorial Evaluation Pending
20 Dec 2022Submission Checks Completed
20 Dec 2022Assigned to Editor
22 Dec 2022Reviewer(s) Assigned
23 Jan 2023Editorial Decision: Revise Major
04 Feb 20232nd Revision Received
06 Feb 2023Submission Checks Completed
06 Feb 2023Assigned to Editor
06 Feb 2023Review(s) Completed, Editorial Evaluation Pending
06 Feb 2023Reviewer(s) Assigned
10 Feb 2023Editorial Decision: Revise Major
17 Feb 20233rd Revision Received
20 Feb 2023Review(s) Completed, Editorial Evaluation Pending
20 Feb 2023Submission Checks Completed
20 Feb 2023Assigned to Editor
22 Feb 2023Reviewer(s) Assigned
02 Mar 2023Editorial Decision: Revise Minor
12 Mar 20234th Revision Received
15 Mar 2023Submission Checks Completed
15 Mar 2023Assigned to Editor
15 Mar 2023Review(s) Completed, Editorial Evaluation Pending
17 Mar 2023Editorial Decision: Accept