This work presents the study on solid-liquid mass transfer performance of suspension in a rotating packed bed (RPB). The calculation model of solid-liquid mass transfer coefficient (ks) is deduced on the basis of the mass conversation law. The ks in RPB is measured using the suspension of cation exchange resin particle reaction with NaOH. The effects of different operating parameters such as pre-dispersion time (t), rotating speed (N), mesh packing thickness (w), liquid volume flow rate (LT), and solid loading (e) are investigated. The results show that the ks increases with the increase of N and w, and increases first and then tends to remain constant with the increase of t and LT. However, the e has no influence on ks. The obtained ks ranges from 1.00×10-5 m/s to 2.60×10-4 m/s which is higher than that in microreactor (MR) under the similar experimental conditions.