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B cell acute lymphoblastic leukemia following mild COVID-19 in an 11-year-old boy
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  • Hui Chen,
  • Qian Xu,
  • Yi Liu,
  • Wenyu Gong,
  • Jun Li,
  • Jing Liang,
  • Xue Zhang,
  • Runhui Wu,
  • Zhenping Chen
Hui Chen
Beijing Children's Hospital
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Qian Xu
Chengdu Women's and Children's Central Hospital
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Yi Liu
Beijing Children's Hospital Capital Medical University
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Wenyu Gong
Beijing Children's Hospital Capital Medical University
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Jun Li
Beijing Key Laboratory of Pediatric Hematology Oncology, National Discipline of Pediatrics, Ministry of Education, MOE Key Laboratory of Major Diseases in Children; Hematology Oncology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health
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Jing Liang
Beijing Children's Hospital Capital Medical University
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Xue Zhang
Beijing Children's Hospital Capital Medical University
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Runhui Wu
Beijing Children's Hospital
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Zhenping Chen
Beijing Children's Hospital Capital Medical University

Corresponding Author:zhenpingchen@outlook.com

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Abstract

Coronavirus disease-2019 (COVID-19) has infected millions of people with high lethality in the world, but little is known whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has impacts on triggering pediatric acute lymphoblastic leukemia (ALL). We present a case of a child with atypical clinical manifestation who developed B-cell acute lymphoblastic leukemia following a mild symptomatic COVID-19 infection. This case underlines the risks of potential oncogenic effects with the history of this viral infection and a state of immunosuppression.