Due to defects of low-voltage and high-current output in new energy power generation system, it is necessary to raise the output voltage and realize further power conversion in the subsequent stage. In this paper, an innovative interleaved high step-up DC-DC converter is proposed. Considering the problems of non-common ground and limited gain in the previously proposed active network DC-DC boost converters, the active network structure is replaced by an interleaved parallel structure, in which charge pump units are employed, and a switched-capacitor unit is added to further improve the voltage gain. Finally, the experimental results of the 150W prototype show that the converter has higher gain, lower voltage stress in switch devices and higher efficiency. When the input voltage and output current are 16V and 1.25A respectively, the efficiency of the entire system can reach about 94.2%.