Pharmacogenetic testing
Genomic DNA was purified and extracted from saliva samples collected using ORAgene DISCOVER kits (OGR-500, DNA Genotek Inc., Ottawa, ON, Canada) with QIAamp DNA Kit (Qiagen Inc., Germantown, MD, USA) per the manufacturer’s protocol. Nine SNPs were genotyped using the iPLEX Gold method (iPLEX Application, Agena, San Diego, CA, USA). Functionality of each gene and supporting evidence for inclusion were described previously20,24,25,32-34 and are summarized in