Fixed parameters |
Fixed parameters |
Fixed
parameters |
Fixed parameters |
CL/fm (L/h) |
1 (7) |
1.05 (10) |
1.04 (0.88,
1.31) |
V/fm (L) |
47.7 (12) |
59.3 (9) |
59.1 (51.3,
71.9) |
Kfm (/h) |
1.1 (fixed) |
1.1 (fixed) |
1.1
(fixed) |
BLurate (mg/dL) |
9.3 (3) |
9.0 (4) |
9.0 (8.3,
9.6) |
Imax (mg/dL) |
6.1 (18) |
7.6 (25) |
7.3 (4.9,
14.4) |
IC50 (mg/L) |
8.0 (53) |
17.6 (48) |
16.5 (6.0,
50.4) |
Effects of covariates on CL/fm |
Effects of covariates on CL/fm |
Effects of covariates on CL/fm |
Effects of covariates on
CL/fm |
Standardized creatinine clearance (power) |
- |
0.45 (31) |
0.46 (0.14,
0.77) |
SLC22A12 rs505802 T allele |
- |
1.32 (36) |
1.32 (1.1,
1.57) |
Effects of covariates on baseline SU |
Effects of
covariates on baseline SU |
Effects of covariates on baseline
SU |
Effects of covariates on baseline SU |
Standardized creatinine clearance (power) |
- |
-0.18 (66) |
-0.18
(-0.42, 0.05) |
PDZK1 rs1219861 A allele on IC50
|
- |
0.73 (32) |
0.73 (0.50, 1.03) |
Random effect parameters, CV% (RSE%) [shrinkage] |
Random effect parameters, CV% (RSE%) [shrinkage] |
Random effect parameters, CV% (RSE%) [shrinkage] |
Random effect parameters, CV% (RSE%)
[shrinkage] |
BSV CL/fm
|
42.8 (9) [0%] |
28.3 (14)
[0%] |
26.5 (19.5, 34.4) |
BSV V/fm
|
40.7 (22) [25%] |
32.4 (21)
[30%] |
31.5 (16.0, 46.3) |
BSV Kfm
|
27.9 (fixed) |
27.9 (fixed) |
27.9
(fixed) |
BSV BLurate
|
11.1 (30) [11%] |
13.7 (18)
[6] |
13.3 (8.6, 19.5) |
BSV Imax
|
32.4 (fixed) |
32.4 (fixed) |
32.4
(fixed) |
BSV IC50
|
71.8 (fixed) |
71.8 (fixed) |
71.8
(fixed) |
Residual error |
Residual error |
Residual
error |
Residual error |
Serum oxypurinol, proportional (CV%) [shrinkage] |
5.2 (33.3)
[23.2%] |
5.2 (17.9) [21.3%] |
5.2 (4.2, 6.1) |
Serum urate, additive (mg/dL) [shrinkage] |
0.90 (53) [16%] |
0.69 (33) [18%] |
0.59 (0.25, 1.08) |