Pharmacogenetic testing
Genomic DNA was purified and extracted from saliva samples collected
using ORAgene DISCOVER kits (OGR-500, DNA Genotek Inc., Ottawa, ON,
Canada) with QIAamp DNA Kit (Qiagen Inc., Germantown, MD, USA) per the
manufacturer’s protocol. Nine SNPs were genotyped using the iPLEX Gold
method (iPLEX Application, Agena, San Diego, CA, USA). Functionality of
each gene and supporting evidence for inclusion were described
previously20,24,25,32-34 and are summarized in