The Effect of ABO Blood Group Incompatibility on Hematopoietic Stem Cell
Transplantation in Children with Aplastic Anemia
Abstract
The influence of ABO incompatibility on transplant results in juvenile
aplastic anemia (SAA) children receiving hematopoietic stem cell
transplantation (HSCT) is debated, and no published data are available.
This study involved 85 children with AA who received hematopoietic stem
cell transplants from donors who were ABO-compatible (n = 38), major
ABO-incompatible (n = 17), minor ABO-incompatible (n = 21), and
bi-directionally incompatible (n = 9). Except for a statistical
difference in acute graft-versus-host disease (aGVHD), the four groups
did not have significantly different chronic GVHD, overall survival, and
neutrophil and platelet implantation rates, and no pure red cell aplasia
or passenger lymphocyte syndrome. Therefore, we inferred that ABO blood
group-incompatible donors do not significantly affect HSCT outcomes and
are not a barrier.