References
1. Kornej J, Börschel CS, Benjamin EJ, Schnabel RB. Epidemiology of Atrial Fibrillation in the 21st Century: Novel Methods and New Insights. Circ Res. 2020;127(1):4-20.
2. Kim MH, Johnston SS, Chu BC, Dalal MR, Schulman KL. Estimation of total incremental health care costs in patients with atrial fibrillation in the United States.Circ Cardiovasc Qual Outcomes. 2011;4(3):313-320.
3. Varela DL, Burnham TS, T May H, et al. Economics and outcomes of sotalol in-patient dosing approaches in patients with atrial fibrillation. J Cardiovasc Electrophysiol. 2022;33(3):333-342.
4. Hoogendoorn ME, Brinkman S, Bosman RJ, Haringman J, de Keizer NF, Spijkstra JJ. The impact of COVID-19 on nursing workload and planning of nursing staff on the Intensive Care: A prospective descriptive multicenter study. Int J Nurs Stud. 2021;121(104005):104005.
5. Samanta R, Thiagalingam A, Turner C, Lakkireddy DJ, Kovoor P. The Use of Intravenous Sotalol in Cardiac Arrhythmias. Heart Lung Circ. 2018;27(11):1318-1326.
6. US FDA Sotalol Hydrochloride Package Insert: Highlights of Prescribing Information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/022306s005lblrpl.pdf
7. Somberg JC, Vinks AA, Dong M, Molnar J. Model-Informed Development of Sotalol Loading and Dose Escalation Employing an Intravenous Infusion. Cardiol Res Pract. 2020;11(5):294-304.
8. Jacobs S, Oren J, Storm R, et al. Abstract 13242: One Day Intravenous Sotalol Loading for Treatment of Atrial Arrhythmia. Circulation. 2021;144(Suppl_1):A13242-A13242.
9. Benditt DG, Williams JH, Jin J, et al. Maintenance of sinus rhythm with oral d,l-sotalol therapy in patients with symptomatic atrial fibrillation and/or atrial flutter. d,l-Sotalol Atrial Fibrillation/Flutter Study Group. Am J Cardiol. 1999;84(3):270-277.
10. Feasibility and Safety of IV Sotalol Administered as a Loading Dose to Initiate Oral Sotalol Therapy - Full Text View - ClinicalTrials.gov. Accessed August 29, 2022. https://clinicaltrials.gov/ct2/show/NCT04473807
11. Prospective Evaluation Analysis and Kinetics Registry - Full Text View - ClinicalTrials.gov. Accessed August 30, 2022. https://clinicaltrials.gov/ct2/show/NCT05247320
12. Surawicz B, Parikh SR. Differences between ventricular repolarization in men and women: description, mechanism and implications. Ann Noninvasive Electrocardiol. 2003;8(4):333-340.
Table 1. Baseline demographics and clinical characteristics of patients receiving intravenous and oral sotalol initiation