Demographics and Clinical Assessment
Patient demographics and clinical characteristics included age, sex,
indication for sotalol initiation, CrCl, and left ventricular ejection
fraction (LVEF). Patient clinical data was manually extracted via chart
review. Heart rates and QT/QTc intervals by ECG were obtained every 15
minutes during sotalol infusion, and 2-4 hours after each oral sotalol
dose. The QT interval was used for decision making when the heart rate
was below 60 bpm. Abnormal QT/QTc intervals during sotalol loading were
verified with manual calculation using the Bazett formula by the
inpatient electrophysiology team. Heart rates and QT/QTc intervals were
subsequently adjudicated by a study investigator.