Conclusion
The use of a one-day IV sotalol loading protocol for atrial and ventricular arrhythmias is safe and well tolerated. It reduces length of stay from an average of 3.6 days to 1 day compared to oral sotalol loading, which can translate into significant cost and resource savings. QT prolongation appears to be near its greatest immediately after sotalol infusion, which suggests discharge after infusion may be possible. Studies evaluating accelerated discharge after a single oral dose as well as an expanded multi-center registry of patients undergoing IV sotalol initiation are forthcoming.