Demographics and Clinical Assessment
Patient demographics and clinical characteristics included age, sex, indication for sotalol initiation, CrCl, and left ventricular ejection fraction (LVEF). Patient clinical data was manually extracted via chart review. Heart rates and QT/QTc intervals by ECG were obtained every 15 minutes during sotalol infusion, and 2-4 hours after each oral sotalol dose. The QT interval was used for decision making when the heart rate was below 60 bpm. Abnormal QT/QTc intervals during sotalol loading were verified with manual calculation using the Bazett formula by the inpatient electrophysiology team. Heart rates and QT/QTc intervals were subsequently adjudicated by a study investigator.