Figure 3.
Activity of neurons recorded from the basolateral amygdala after short- (WD1-3) and long- (WD26-45) term withdrawal from chronic cocaine and yoked saline . Histological slice showing a Chicago sky blue deposit dot in the BLA (A). Representative electrophysiological trace of a BLA neurons showing the presence of triplet and doublet of spikes (black arrows). Inset represents the shape of action potentials (averaged over 5 minutes), with the action potential duration is measured from peak to trough (dashed line) (B). Two-minute representative electrophysiological trace of a BLA neurons recorded from (top to bottom) : saline WD1-3, cocaine WD1-3, saline WD26-45 and cocaine WD26-45 rats (C). Number of action potentials per second (firing rate; top) and percentage of action potentials firing in burst (bottom). On the left, individual data points and mean ± SEM; on the right, mean ± SEM and statistics (D). *p<0.05. saline WD1-3: 35 neurons; cocaine WD1-3: 30 neurons; saline WD26-45: 36 neurons; cocaine WD26-45: 56 neurons. Coronal brain sections adapted from (Swanson, 2018).