Figure 2.
Dopaminergic activity in the ventral tegmental area after short-
(WD1) and long- (WD30) term withdrawal from chronic cocaine and yoked
saline. Histological slice showing a Chicago sky blue deposit dot in
the VTA (A). Mean number of spontaneously active DA neurons recorded per
electrode track (B), number of spikes per second (firing rate) and
percentage of action potential firing in bursts (D) in saline/naive and
cocaine rats after 18h-72h (WD 1-3) and saline/naive and cocaine rats
after 26-45 days after the last self-administration session (WD 26-45).
Data are mean ± SEM; *p<0.05; saline/naive WD1-3: 9 rats (5
saline, 4 naive), 65 neurons; cocaine WD1-3: 5 rats, 60 neurons;
saline/naive WD26-45: 9 rats (6 Saline, 3 naïve), 65 neurons; cocaine
WD26-45: 6 rats, 30 neurons. Coronal brain sections adapted from
(Swanson, 2018).