Figure 5.
Effect of blocking glutamatergic afferents with kynurenic acid in the ventral pallidum on VTA DA neuron activity. Histological slice showing track of the guide cannula in the VP (A). Coronal brain section adapted from (Swanson, 2018) (VEH: black dots; KYN: white and black dots) (B). Number of spontaneously active DA neurons recorded per electrode track (C, left), number of spikes per second (firing rate; C, middle) and percentage of action potential firing in bursts (C, right) in cocaine WD30 rats after VEH or KYN infusion in the VP. Data are mean ± SEM; *p<0.05; cocaine WD26-45 VEH: 5 rats, 27 neurons; cocaine WD26-45 KYN: 5 rats, 49 neurons. Coronal brain sections adapted from (Swanson, 2018).