Figure 1.
Self-administration and relapse test. Experimental design
timeline (A). Number of active (black) and inactive (white) nose-pokes
during the 10 sessions in cocaine rats (B) and in yoked saline rats (C).
Number of cocaine injections (0.75mg/kg/infusion) during the ten
self-administration sessions (D). Number of active responses during
cocaine-seeking over 1 h-session 24h (WD1) and 30 days (WD30) after the
last self-administration session (E).
Data are mean ± SEM; *p<0.05; cocaine rats: n= 53, yoked
saline rats: n = 21, cocaine seeking: n=6.