Figure 1.
Self-administration and relapse test. Experimental design timeline (A). Number of active (black) and inactive (white) nose-pokes during the 10 sessions in cocaine rats (B) and in yoked saline rats (C). Number of cocaine injections (0.75mg/kg/infusion) during the ten self-administration sessions (D). Number of active responses during cocaine-seeking over 1 h-session 24h (WD1) and 30 days (WD30) after the last self-administration session (E).
Data are mean ± SEM; *p<0.05; cocaine rats: n= 53, yoked saline rats: n = 21, cocaine seeking: n=6.