Cocaine self-administration and cocaine seeking behavior after 1
and 30 days of withdrawal
All rats were allowed to self-administer cocaine for 10 sessions under
an FR1 schedule of reinforcement. During the 10 sessions of
self-administration, cocaine rats had more active than inactive
nose-pokes (Figure 1B; n=53), whereas there were no differences in yoked
saline rats (Figure 1C; n=21). The number of injections was stable
across the self-administration sessions in cocaine rats (Figure 1D). As
previously described (Grimm et al., 2001; Chauvet et al., 2012), cocaine
seeking (measured in a 1h-extinction session) was significantly higher
after 30 days of withdrawal compared to 1 day of withdrawal (Figure 1E;
n=6).