Figure 3.
Activity of neurons recorded from the basolateral amygdala after
short- (WD1-3) and long- (WD26-45) term withdrawal from chronic cocaine
and yoked saline . Histological slice showing a Chicago sky blue deposit
dot in the BLA (A). Representative electrophysiological trace of a BLA
neurons showing the presence of triplet and doublet of spikes (black
arrows). Inset represents the shape of action potentials (averaged over
5 minutes), with the action potential duration is measured from peak to
trough (dashed line) (B). Two-minute representative electrophysiological
trace of a BLA neurons recorded from (top to bottom) : saline WD1-3,
cocaine WD1-3, saline WD26-45 and cocaine WD26-45 rats (C). Number of
action potentials per second (firing rate; top) and percentage of action
potentials firing in burst (bottom). On the left, individual data points
and mean ± SEM; on the right, mean ± SEM and statistics (D).
*p<0.05. saline WD1-3: 35 neurons; cocaine WD1-3: 30 neurons;
saline WD26-45: 36 neurons; cocaine WD26-45: 56 neurons. Coronal brain
sections adapted from (Swanson, 2018).