Cocaine self-administration and cocaine seeking behavior after 1 and 30 days of withdrawal
All rats were allowed to self-administer cocaine for 10 sessions under an FR1 schedule of reinforcement. During the 10 sessions of self-administration, cocaine rats had more active than inactive nose-pokes (Figure 1B; n=53), whereas there were no differences in yoked saline rats (Figure 1C; n=21). The number of injections was stable across the self-administration sessions in cocaine rats (Figure 1D). As previously described (Grimm et al., 2001; Chauvet et al., 2012), cocaine seeking (measured in a 1h-extinction session) was significantly higher after 30 days of withdrawal compared to 1 day of withdrawal (Figure 1E; n=6).