Figure 2.
Dopaminergic activity in the ventral tegmental area after short- (WD1) and long- (WD30) term withdrawal from chronic cocaine and yoked saline. Histological slice showing a Chicago sky blue deposit dot in the VTA (A). Mean number of spontaneously active DA neurons recorded per electrode track (B), number of spikes per second (firing rate) and percentage of action potential firing in bursts (D) in saline/naive and cocaine rats after 18h-72h (WD 1-3) and saline/naive and cocaine rats after 26-45 days after the last self-administration session (WD 26-45).
Data are mean ± SEM; *p<0.05; saline/naive WD1-3: 9 rats (5 saline, 4 naive), 65 neurons; cocaine WD1-3: 5 rats, 60 neurons; saline/naive WD26-45: 9 rats (6 Saline, 3 naïve), 65 neurons; cocaine WD26-45: 6 rats, 30 neurons. Coronal brain sections adapted from (Swanson, 2018).