Sensitivity analysis
Sensitivity analyses were performed to examine the model’s robustness considering possible real-life variations and uncertainties. In the sensitivity analysis, we assign a range, rather than a single value, to the model variables. One-way sensitivity analysis on all the model variables also was used to assess the contribution of each variable to the final results. To evaluate the influence of the genetic status on the utility profile of each strategy, we performed a two-way sensitivity analysis for the utility of AS state vs. the utility post-HT state, for both BRAFV600E positive and negative status.