Sensitivity analysis
Sensitivity analyses were performed to examine the model’s robustness
considering possible real-life variations and uncertainties. In the
sensitivity analysis, we assign a range, rather than a single value, to
the model variables. One-way sensitivity analysis on all the model
variables also was used to assess the contribution of each variable to
the final results. To evaluate the influence of the genetic status on
the utility profile of each strategy, we performed a two-way sensitivity
analysis for the utility of AS state vs. the utility post-HT state, for
both BRAFV600E positive and negative status.