DESCRIPTION VALUE LOW HIGH
Probabilities Probabilities Probabilities Probabilities
HR for tumor growth of BRAFV600E positive vs. BRAFV600E negative 3.55 3 4
HR for tumor recurrence of BRAFV600E positive vs. BRAFV600E negative 3.55 3 4
Probability of a long-term complication from HT 0.0154 0.013 0.017
Probability of growth of the primary tumor during AS for patients aged 40–59 years old 0.0091 0.0082 0.01
Probability of growth of the primary tumor during AS for patients more than 60 years old 0.004 0.0036 0.0044
Probability of loco-regional disease during AS for patients aged 40–59 years old 0.0023 0.0021 0.0025
Probability of loco-regional disease during AS for patients more than 60 years old 0.00050 0.00045 0.00055
Probability of recurrence after HT 0.00400 0.003 0.005
Model structure variables Model structure variables Model structure variables Model structure variables
Age 40 35 45
Discount rate 0 0 0.05
Time horizon 100 90 110
Utilities values Utilities values Utilities values Utilities values
Utility during AS health state 0.88 0.8 1
Utility of disease recurrence 0.54 0.5 0.7
Utility of disease-free state after HT with complication 0.63 0.5 0.7
Utility of disease-free state after HT without complication 0.99 0.8 1