Abstract There are two simple concrete methods to reduce the dosage of NSAIDs dramatically. An attending physician is suspected of being a fake doctor if the blood test is never performed after administration of the antihyperlipidemic drug. However, the analgesic effects are often not examined after the administration of analgesics. As with antihyperlipidemic drugs, efficacy should be examined after administration of analgesics. Analgesics should not be administered continuously without examining the analgesic effects. One study shows no difference in the analgesic effects between NSAIDs and acetaminophen at the latest 2 weeks after injury or surgery. If NSAIDs are administered for more than 2 weeks, it is necessary to confirm that NSAIDs are more analgesic than acetaminophen. If NSAIDs are more analgesic than acetaminophen, prolonged administration of NSAIDs is acceptable, knowing that they have more adverse effects than acetaminophen. If the analgesic effects of both medicines are comparable, acetaminophen should be administered. These are a matter of course. The two methods reduce the administration of NSAIDs dramatically, reducing the aforementioned adverse effects due to NSAIDs dramatically.

As a general rule in pharmacotherapy, ineffective pharmacological treatment should be discontinued. Ineffective pharmacotherapy should not be administered for a long time. The first problem is the appropriate duration to determine that the pharmacological treatment is ineffective. The second problem is the criterion for determining the efficacy (or ineffectiveness) of the pharmacological treatment. As far as I know, there is no evidence regarding the duration. Nevertheless, it is necessary to determine the duration. Standards by academic organizations are necessary, even provisional standards are acceptable. Long-term administration of ineffective medicine causes the problem of adverse effects. It loses the opportunity to receive effective treatment. In case that HT is ineffective for menopause, the treatment of fibromyalgia may relieve symptoms of menopause. Patients do not get medical attention for the improvement of abnormal hormone levels but do for the improvement of subjective symptoms such as widespread pain, numbness, insomnia, and fatigue. Some people are almost asymptomatic even if their hormone levels are abnormal. I believe that the efficacy (or ineffectiveness) should be determined with the improvement of the above-mentioned subjective symptoms rather than the improvement of the abnormal hormone levels.