PCIS can be used to study anti-allergic drugs
Antihistamines were used to demonstrate the suitability of PCIS as a model of FA to assess specific mechanisms of action. Pre-treatment of the tissue with the antihistamines diphenhydramine hydrochloride, cetirizine dihydrochloride and rupatadine resulted in significant suppression of contraction responses to histamine stimulation (Figure 4D).