Peanut OIT suppresses allergen-specific responses
As a promising treatment option for FA, the suppression of allergic responses following OIT was also investigated using the PCIS model. PCIS passively sensitized with plasma from a peanut allergic individual pre-peanut OIT, stimulated with PE resulted in a strong smooth muscle contraction response (Figure 5). Following completion of the OIT protocol, plasma from the same individual resulted in a diminished response after stimulation with PE, which is reflective of the clinical phenotype of the plasma donor. Co-incubation of pre- and post-OIT plasma also resulted in a reduced contraction response in comparison to the pre-OIT condition, reflecting the sensitivity of the model (Figure 5).