Methods
The study was conducted in two stages. Firstly, we developed the
analytical methodology to assess the compatibility of the two sentinel
products of OXY injection (10IU/mL) and TXA injection (100mg/mL) in
200mL infusion bags of both 0.9%w/v saline and Ringer’s Lactate. We
analysed all TXA-OXY combinations, and each evaluation was conducted for
up to 6hrs. Based on the results from these investigations, the second
stage comprised a screen of the compatibility of multiple TXA products
with reference OXY products (5 IU/mL and 10 IU/mL) when mixed in
0.9%w/v saline in glass vials over a period of 1 hour.