Longitudinal Trajectory Characteristics of FTR
Left heart valve surgery can only reduce the afterload, but cannot solve TA dilation or improve the preload and RV function, and there is still a possibility of FTR progression in the long term[6]. In this study, GBTM model, a statistical method, was adopted to consider FTR information and FTR changes of multiple measurements, and finally realized the transformation from ”FTR at a single time point or cumulative FTR level exposure” to ”dynamic FTR longitudinal trajectory”. According to grouping selection basis of GBTM model, the study determined three postoperative FTR longitudinal trajectory groups, namely ”stable group”, ”increasing-slow group” and ”increasing-fast group”. Among them, patients belonging to the ”stable group” always had a low postoperative FTR level, and no significant change was observed within 5 years after surgery. Patients in the ” increasing-slow group” had a continuous worsening of FTR after MVR, and the severity of FTR was still less than 10.0 cm² at the end of follow-up. Patients assigned to the ” increasing-fast group” had relatively large baseline FTR, which continued to rise rapidly after MVR and deteriorated to severe FTR about 3 years after surgery. Although there has been no literature discussion on the longitudinal trajectory of FTR in the past, this study is consistent with the results of relevant studies in recent years, and FTR of some patients will deteriorate to varying degrees with the extension of postoperative time[10].