Characterization of Trajectories of FTR
According to GBTM model grouping selection, three different FTR longitudinal trajectory groups were determined in patients undergoing MVR(Figure 2), with polynomial order 1, 2 and 2 respectively(Supplementary table 1), including ”stable group”(258 cases, 68.2%), ”increasing-slow group”(67 cases, 17.6%), and ”increasing-fast group”(53 cases, 14.2%). In terms of model validation, the AvePP were all greater than 0.7(Supplementary table 2), the number of people assigned to each track group was close to the estimated value of the model(Supplementary table 3), and the occurrence ratios of correctly assigned to the track group were all greater than 5(Supplementary table 4), indicating that the model fitting was ideal. Table 1 shows preoperative clinical characteristics for all patients. The length of medical history, age, female, complications of AF and PH, LAD, TRA, RATD, RALD and LVEDD showed significant difference among the three different FTR longitudinal trajectory groups(p <0.05).