Spontaneous Intramural left atrial hematoma that mimics a primary or metastatic cardiac tumor is a very rare entity. We report a case of a 60-year-old man suffering from chronic myeloid leukemia, who was admitted for prolonged chest pain and fatigue. Transthoracic echocardiography revealed a left atrial mass in close proximity to the posterior mitral annulus and failed to provide an ethiological diagnosis. Surgical management was utilized to outrule the atrial neoplasm and to prevent emboli, obstruction and mitral valve insufficiency. This is the first case in the literature in which robot-assisted minimally invasive surgery was adopted to manage such a rare entity.