Functional role of ST6GALNAC1-mediated sialylation of mucins in
preserving intestinal barrier integrity and ameliorating inflammation.
Authors : Elisa Sánchez-Martínez1*, Manuel
Garrido-Romero1,2,*, F. Javier
Moreno2
1Department
of Immunology, Instituto de Investigación Sanitaria Hospital
Universitario de La Princesa, (IIS-Princesa), Universidad Autónoma de
Madrid (UAM), Madrid, Spain.
2Department of Bioactivity and Food Analysis,
Instituto de Investigación en Ciencias de la Alimentación, CIAL
(CSIC-UAM), Madrid, Spain.
*Equal contribution
Correspondence to:F. Javier Moreno. Department of Bioactivity and Food Analysis, Instituto
de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM),
Nicolás Cabrera 9, 28049 Madrid, Spain.
E-mail:javier.moreno@csic.es
Abbreviations:ST6GALNAC1, ST6; mucin-2, MUC2;
dextran sulfate sodium,
DSS; wild-type, WT; short-chain fatty acids, SCFA.
Funding
information : MGR is
supported by an EFSA project (Grant agreement GP/EFSA/ENCO/2020/02 – 1)
granted to FJM. Conclusions, findings and opinions expressed in this
document reflect only the view of the authors and not the official
position of EFSA.
Keywords: epithelial barrier; MUC2; intestinal mucus; gut
microbiota disruption; colitis.