Statistical analysis
Statistical analysis was performed with JMP 12.0.1© Software (SAS
institute, Cary NC, USA). Numeric variables are expressed in means with
standard error of means (means ± SEM) and categorial data as absolute
numbers and percentages. Continuous data were tested using T-Test,
categorial variables with the Fisher-exact test. Time-to-event analysis
were performed using Kaplan-Meier method and a logrank-test. A p-value
<0.05 was considered statistically significant.